MICU2 Restricts Spatial Crosstalk between InsP(3)R and MCU Channels by Regulating Threshold and Gain of MICU1-Mediated Inhibition and Activation of MCU

Payne, R; Hoff, H; Roskowski, A; Foskett, JK

Foskett, JK (reprint author), Univ Penn, Perelman Sch Med, Dept Physiol, Philadelphia, PA 19104 USA.; Foskett, JK (reprint author), Univ Penn, Perelman Sch Med, Dept Cell & Dev Biol, Philadelphia, PA 19104 USA.

CELL REPORTS, 2017; 21 (11): 3141

Abstract

Ca2+ entry into mitochondria is mediated by the Ca2+ uniporter-channel complex containing MCU, the Ca2+-selective pore, and associated regulatory prot......

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