Pharmacokinetics of TAK-875 and its toxic metabolite TAK-875-acylglucuronide in rat plasma by liquid chromatography tandem mass spectrometry

Qiang, YZ; Zhang, XH

Zhang, XH (reprint author), Inner Mongolia Med Univ, Affiliated Hosp, Dept Pharm, Xinhua Rd, Hohot 010059, Inner Mongolia, Peoples R China.

BIOMEDICAL CHROMATOGRAPHY, 2019; 33 (3):

Abstract

TAK-875 is a selective partial agonist of human GPR40 receptor, which was unexpectedly terminated at phase III clinical trials owing to its severe hep......

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