Reengineering Ponatinib to Minimize Cardiovascular Toxicity

Hnatiuk, AP; Bruyneel, AAN; Tailor, D; Pandrala, M; Dheeraj, A; Li, WQ; Serrano, R; Feyen, DAM; Vu, MM; Amatya, P; Gupta, S; Nakauchi, Y; Morgado, I; Wiebking, V; Liao, RL; Porteus, MH; Majeti, R; Malhotra, SV; Mercola, M

Mercola, M (通讯作者)，Stanford Cardiovasc Inst, Biomed Innovat Bldg,Room 3300,240 Pasteur Dr, Palo Alto, CA 94304 USA.;Malhotra, SV (通讯作者)，2720 S Moody Ave,KCRB 2126, Portland, OR 97201 USA.

CANCER RESEARCH, 2022; 82 (15): 2777

Abstract

Small molecule tyrosine kinase inhibitors (TKI) have revo-lutionized cancer treatment and greatly improved patient sur-vival. However, life-threatenin......

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