Safety, pharmacodynamics, and potential benefit of omaveloxolone in Friedreich ataxia

Lynch, DR; Farmer, J; Hauser, L; Blair, IA; Wang, QQ; Mesaros, C; Snyder, N; Boesch, S; Chin, M; Delatycki, MB; Giunti, P; Goldsberry, A; Hoyle, C; McBride, MG; Nachbauer, W; O'Grady, M; Perlman, S; Subramony, SH; Wilmot, GR; Zesiewicz, T; Meyer, C

Lynch, DR (reprint author), Childrens Hosp Philadelphia, Div Neurol, 502 Abramson Res Ctr, 3615 Civ Ctr Blvd, Philadelphia, PA 19104 USA.

ANNALS OF CLINICAL AND TRANSLATIONAL NEUROLOGY, 2019; 6 (1): 15

Abstract

Objective Previous studies have demonstrated that suppression of Nrf2 in Friedreich ataxia tissues contributes to excess oxidative stress, mitochondri......

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