Polyclonal RB1 mutations and acquired resistance to CDK 4/6 inhibitors in patients with metastatic breast cancer

Condorelli, R; Spring, L; O'Shaughnessy, J; Lacroix, L; Bailleux, C; Scott, V; Dubois, J; Nagy, RJ; Lanman, RB; Iafrate, AJ; Andre, F; Bardia, A

Bardia, A (reprint author), Harvard Med Sch, Massachusetts Gen Hosp, Ctr Canc, Lawrence House 304,10 North Grove St, Boston, MA 02114 USA.

ANNALS OF ONCOLOGY, 2018; 29 (3): 640

Abstract

While deregulation of the cyclin D1-CDK4/6-retinoblastoma pathway is common in hormone receptor positive (HR+) breast cancer, Rb is usually intact in ......

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