Computational Modelling of Metabolic Burden and Substrate Toxicity in Escherichia coli Carrying a Synthetic Metabolic Pathway

Demko, M; Chrast, L; Dvorak, P; Damborsky, J; Safranek, D

Safranek, D (reprint author), Masaryk Univ, Fac Informat, Syst Biol Lab, Bot 68a, Brno 60200, Czech Republic.; Damborsky, J (reprint author), Masaryk Univ, Fac Sci, Dept Expt Biol, Kamenice 5,Bld A13, Brno 62500, Czech Republic.; Damborsky, J (reprint aut

MICROORGANISMS, 2019; 7 (11):

Abstract

In our previous work, we designed and implemented a synthetic metabolic pathway for 1,2,3-trichloropropane (TCP) biodegradation in Escherichia coli. S......

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