BOLA (BolA Family Member 3) Deficiency Controls Endothelial Metabolism and Glycine Homeostasis in Pulmonary Hypertension

Yu, QJ; Tai, YY; Tang, Y; Zhao, JS; Negi, V; Gulley, MK; Pilli, J; Sun, W; Brugger, K; Mayr, J; Saggar, R; Saggar, R; Wallace, WD; Ross, DJ; Waxman, AB; Wendell, SG; Mullett, SJ; Sembrat, J; Rojas, M; Khan, OF; Dahlman, JE; Sugahara, M; Kagiyama, N;

Chan, SY (reprint author), Univ Pittsburgh, Pittsburgh Heart Lung Blood & Vasc Med Inst, Ctr Pulm Vasc Biol & Med, Div Cardiol,Dept Med,Med Ctr, 200 Lothrop St BST1704-2, Pittsburgh, PA 15261 USA.

CIRCULATION, 2019; 139 (19): 2238

Abstract

BACKGROUND: Deficiencies of iron-sulfur (Fe-S) clusters, metal complexes that control redox state and mitochondrial metabolism, have been linked to pu......

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