Combined immunotherapy with controlled interleukin-12 gene therapy and immune checkpoint blockade in recurrent glioblastoma: An open-label, multi-institutional phase I trial

Chiocca, EA; Gelb, AB; Chen, CC; Rao, G; Reardon, DA; Wen, PY; Bi, WL; Peruzzi, P; Amidei, C; Triggs, D; Seften, L; Park, G; Grant, J; Truman, K; Buck, JY; Hadar, N; Demars, N; Miao, J; Estupinan, T; Loewy, J; Chadha, K; Tringali, J; Cooper, L; Lukas, RV

Chiocca, EA (通讯作者)，Harvard Med Sch, Dept Neurosurg, Hale Bldg 4th Floor,60 Fenwood Rd, Boston, MA 02115 USA.;Chiocca, EA (通讯作者)，Brigham & Womens Hosp, Hale Bldg 4th Floor,60 Fenwood Rd, Boston, MA 02115 USA.

NEURO-ONCOLOGY, 2022; 24 (6): 951

Abstract

Background Veledimex (VDX)-regulatable interleukin-12 (IL-12) gene therapy in recurrent glioblastoma (rGBM) was reported to show tumor infiltration of......

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