Asymmetric Synthesis of Fluoro-MLN4924 as a Selective NEDD8-Activating Enzyme (NAE) Inhibitor

Kim, HR; Jarhad, DB; Sahu, PK; Sung, K; An, D; Hyun, YE; Yu, JH; Jeong, LS

Yu, JH; Jeong, LS (reprint author), Seoul Natl Univ, Coll Pharm, Res Inst Pharmaceut Sci, Seoul 08826, South Korea.

ASIAN JOURNAL OF ORGANIC CHEMISTRY, 2019; 8 (9): 1641

Abstract

Based on bioisosteric rationale, fluorinated analogues of MLN4924, which is a selective NEDD8-activating enzyme inhibitor, were designed and their asy......

Full Text Link


Links

期刊讨论 | 中国SCI论文 | 期刊主页 | 投稿经验 | 杂志官网 | 投稿链接 | 作者需知 | PMC链接 | Pubmed全文检索