CRISPR/Cas9-targeting of CD40 in hematopoietic stem cells limits immune activation mediated by anti-CD40

Wang, R; Graham, S; Sun, N; McCarthy, D; Peng, RQ; Erickson, J; Oconnor, L; Zhu, XC; Wurbel, M; Dunstan, R; Westmoreland, S; Chung, NJ; Ghayur, T; Gu, JJ

Wang, R (corresponding author), AbbVie, Cambridge Res Ctr, Cambridge, MA 02139 USA.

PLOS ONE, 2020; 15 (3):

Abstract

Inflammatory bowel diseases (IBD) are complex, multifactorial disorders characterized by chronic relapsing intestinal inflammation. IBD is diagnosed a......

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