Identification and structure-activity relationship of purine derivatives as novel MTH1 inhibitors

Kumar, A; Kawamura, T; Kawatani, M; Osada, H; Zhang, KYJ

Zhang, KYJ (reprint author), RIKEN Ctr Life Sci Technol, Struct Bioinformat Team, Yokohama, Kanagawa, Japan.; Osada, H (reprint author), RIKEN Ctr Sustainable Resource Sci, Chem Biol Res Grp, Wako, Saitama, Japan.

CHEMICAL BIOLOGY & DRUG DESIGN, 2017; 89 (6): 862

Abstract

The human mutT homolog-1 (MTH1) protein prevents the incorporation of oxidized nucleotides such as 2-OH-dATP and 8-oxo-dGTP during DNA replication by ......

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