Cancer cells with defective oxidative phosphorylation require endoplasmic reticulum-to-mitochondria Ca2+ transfer for survival

Cardenas, C; Lovy, A; Silva-Pavez, E; Urra, F; Mizzoni, C; Ahumada-Castro, U; Bustos, G; Jana, F; Cruz, P; Farias, P; Mendoza, E; Huerta, H; Murgas, P; Hunter, M; Rios, M; Cerda, O; Georgakoudi, I; Zakarian, A; Molgo, J; Foskett, JK

Cardenas, C (corresponding author), Univ Mayor, Fac Sci, Ctr Integrat Biol, Santiago 8580745, Chile.; Cardenas, C (corresponding author), Gerosci Ctr Brain Hlth & Metab, Santiago 8580745, Chile.; Cardenas, C (corresponding author), Buck Inst Res Aging, Novato, CA 94945 USA.; Cardenas, C (corresponding author), Univ Calif Santa Barbara, Dept Chem & Biochem, Santa Barbara, CA 93106 USA.; Foskett, JK (corresponding author), Univ Penn, Dept Physiol, Perelman Sch Med, Philadelphia, PA 19104 USA.; Foskett, JK (corresponding author), Univ Penn, Dept Cell & Dev Biol, Perelman Sch Med, Philadelphia, PA 19104 USA.

SCIENCE SIGNALING, 2020; 13 (640):

Abstract

Spontaneous Ca2+ signaling from the InsP(3)R intracellular Ca2+ release channel to mitochondria is essential for optimal oxidative phosphorylation (OX......

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