Differential effects of intrauterine growth restriction and a hypersinsulinemic-isoglycemic clamp on metabolic pathways and insulin action in the fetal liver

Jones, AK; Brown, LD; Rozance, PJ; Serkova, NJ; Hay, WW; Friedman, JE; Wesolowski, SR

Wesolowski, SR (reprint author), Univ Colorado, Dept Pediat, Perinatal Res Ctr, Mail Stop F441, Aurora, CO 80045 USA.

AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY, 2019; 316 (5): R427

Abstract

Intrauterine growth-restricted (IUGR) fetal sheep have increased hepatic glucose production (HGP) that is resistant to suppression during a hyperinsul......

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