Development of novel ultra-sensitive IL-11 target engagement assays to support mechanistic PK/PD modeling for an anti-IL-11 antibody therapeutic

Myzithras, M; Lin, SQ; Radden, L; Kenny, CH; Cai, Z; MacDonald, A; Binetti, R; Marlow, M; Fracasso, P; Gibson, G; Bartlett, C; Hawkins, J; Hansel, S

Myzithras, M (通讯作者)，Biotherapeut Discovery, Res, Ridgefield, CT 06877 USA.

MABS, 2022; 14 (1):

Abstract

An in-house antibody generation campaign identified a diverse, high affinity set of anti-interleukin-11 (IL-11) monoclonal antibodies (mAbs) to enable......

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