Trans-signaling of interleukin-6 (IL-6) is mediated by the soluble IL-6 receptor, but not by soluble CD5

Aparicio-Siegmund, S; Deseke, M; Lickert, A; Garbers, C

Garbers, C (reprint author), Univ Kiel, Inst Biochem, Olshausenstr 40, D-24118 Kiel, Germany.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2017; 484 (4): 808

Abstract

IL-6 exerts its pleiotropic activities on its target cells via the IL-6 alpha-receptor (IL-6R), which is expressed on a limited number of cell types. ......

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