Oral Bruton tyrosine kinase inhibitors block activation of the platelet Fc receptor CD32a (Fc gamma RIIA): a new option in HIT?

Goldmann, L; Duan, RD; Kragh, T; Wittmann, G; Weber, C; Lorenz, R; von Hundelshausen, P; Spannagl, M; Siess, W

Siess, W (reprint author), Ludwig Maximilians Univ Munchen, Klinikum Innenstadt, Inst Prophylaxe & Epidemiol Kreislaufkrankheiten, Pettenkoferstr 9, D-80336 Munich, Germany.

BLOOD ADVANCES, 2019; 3 (23): 4021

Abstract

Activation of the platelet Fc-receptor CD32a (Fc gamma RIIA) is an early and crucial step in the pathogenesis of heparin-induced thrombocytopenia type......

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