Endogenous MicroRNA Competition as a Mechanism of shRNA-Induced Cardiotoxicity

Course, MM; Gudsnuk, K; Desai, N; Chamberlain, JR; Valdmanis, PN

Valdmanis, PN (corresponding author), Univ Washington, Div Med Genet, Sch Med, 1705 NE Pacific St,HSB J-305,Box 357720, Seattle, WA 98195 USA.

MOLECULAR THERAPY-NUCLEIC ACIDS, 2020; 19 (): 572

Abstract

Gene knockdown using short hairpin RNAs (shRNAs) is a promising strategy for targeting dominant mutations; however, delivering too much shRNA can disr......

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