Kindlin-2 Mediates Mechanical Activation of Cardiac Myofibroblasts

Godbout, E; Son, DO; Hume, S; Boo, S; Sarrazy, V; Clement, S; Kapus, A; Wehrle-Haller, B; Bruckner-Tuderman, L; Has, C; Hinz, B

Hinz, B (corresponding author), Univ Toronto, Fac Dent, Lab Tissue Repair & Regenerat, Toronto, ON M5G 1G6, Canada.

CELLS, 2020; 9 (12):

Abstract

We identify the focal adhesion protein kindlin-2 as player in a novel mechanotransduction pathway that controls profibrotic cardiac fibroblast to myof......

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