Structures of p53/BCL-2 complex suggest a mechanism for p53 to antagonize BCL-2 activity

Wei, HD; Wang, HL; Wang, GX; Qu, LZ; Jiang, LY; Dai, SY; Chen, XJ; Zhang, Y; Chen, ZC; Li, YJ; Guo, M; Chen, YH

Guo, M; Chen, YH (通讯作者)，Cent South Univ, Xiangya Hosp, Dept Oncol, NHC Key Lab Canc Prote, Changsha 410008, Hunan, Peoples R China.;Guo, M; Chen, YH (通讯作者)，Cent South Univ, Xiangya Hosp, Natl Clin Res Ctr Geriatr Disorders, State Local Joint Engn Laboratroy Anticanc Drugs, Changsha 410008, Hunan, Peoples R China.

NATURE COMMUNICATIONS, 2023; 14 (1):

Abstract

Mitochondrial apoptosis is strictly controlled by BCL-2 family proteins through a subtle network of protein interactions. The tumor suppressor protein......

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