Gasdermin E suppresses tumour growth by activating anti-tumour immunity

Zhang, ZB; Zhang, Y; Xia, SY; Kong, Q; Li, SY; Liu, X; Junqueira, C; Meza-Sosa, KF; Mok, TMY; Ansara, J; Sengupta, S; Yao, YD; Wu, H; Lieberman, J

Zhang, ZB; Lieberman, J (corresponding author), Boston Childrens Hosp, Program Cellular & Mol Med, Boston, MA 02115 USA.; Zhang, ZB; Lieberman, J (corresponding author), Harvard Med Sch, Dept Pediat, Boston, MA 02115 USA.

NATURE, 2020; 579 (7799): 415

Abstract

Cleavage of the gasdermin proteins to produce pore-forming amino-terminal fragments causes inflammatory cell death (pyroptosis)(1). Gasdermin E (GSDME......

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