BRCA locus-specific loss of heterozygosity in germline BRCA1 and BRCA2 carriers

Maxwell, KN; Wubbenhorst, B; Wenz, BM; De Sloover, D; Pluta, J; Emery, L; Barrett, A; Kraya, AA; Anastopoulos, IN; Yu, S; Jiang, YC; Chen, H; Zhang, NR; Hackman, N; D'Andrea, K; Daber, R; Morrissette, JJD; Mitra, N; Feldman, M; Domchek, SM; Nathanson

Nathanson, KL (reprint author), Univ Penn, Perelman Sch Med, Dept Med, Div Translat Med & Human Genet, Philadelphia, PA 19104 USA.; Nathanson, KL (reprint author), Univ Penn, Perelman Sch Med, Basser Ctr BRCA, Philadelphia, PA 19104 USA.; Nathanson, KL (r

NATURE COMMUNICATIONS, 2017; 8 ( ):

Abstract

Complete loss of BRCA1 or BRCA2 function is associated with sensitivity to DNA damaging agents. However, not all BRCA1 and BRCA2 germline mutation-ass......

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