Sites associated with Kalydeco binding on human Cystic Fibrosis Transmembrane Conductance Regulator revealed by Hydrogen/Deuterium Exchange

Byrnes, LJ; Xu, YR; Qiu, XY; Hall, JD; West, GM

West, GM (reprint author), Pfizer, Struct & Mol Sci, 445 Eastern Point Rd, Groton, CT 06340 USA.

SCIENTIFIC REPORTS, 2018; 8 ():

Abstract

Cystic Fibrosis (CF) is caused by mutations in the Cystic Fibrosis Transmembrane Conductance Regulator (CFTR). Mutations associated with CF cause loss......

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