Titin (TTN): from molecule to modifications, mechanics, and medical significance

Loescher, CM; Hobbach, AJ; Linke, WA

Linke, WA (通讯作者),Univ Hosp Munster, Dept Cardiol Coronary Peripheral Vasc Dis & Heart, Albert Schweitzer Campus 1,Bldg A1, D-48149 Munster, Germany.

CARDIOVASCULAR RESEARCH, 2022; 118 (14): 2903

Abstract

The giant sarcomere protein titin is a major determinant of cardiomyocyte stiffness and contributor to cardiac strain sensing. Titin-based forces are ......

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