Structural Basis for the RNA-Guided Ribonuclease Activity of CRISPR-Cas13d

Zhang, C; Konermann, S; Brideau, NJ; Lotfy, P; Wu, XB; Novick, SJ; Strutzenberg, T; Griffin, PR; Hsu, PD; Lyumkis, D

Lyumkis, D (reprint author), Salk Inst Biol Studies, Lab Genet, 10010 N Torrey Pines Rd, La Jolla, CA 92037 USA.; Hsu, PD (reprint author), Salk Inst Biol Studies, Lab Mol & Cell Biol, 10010 N Torrey Pines Rd, La Jolla, CA 92037 USA.; Hsu, PD; Lyumkis, D

CELL, 2018; 175 (1): 212

Abstract

CRISPR-Cas endonucleases directed against foreign nucleic acids mediate prokaryotic adaptive immunity and have been tailored for broad genetic enginee......

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