Decoding the Conformational Selective Mechanism of FGFR Isoforms: A Comparative Molecular Dynamics Simulation

Zhang, MY; Yasen, M; Lu, SY; Ma, DN; Chai, ZT

Lu, SY (通讯作者)，Shanghai Jiao Tong Univ, Sch Med, Med Chem & Bioinformat Ctr, Shanghai 200025, Peoples R China.;Lu, SY (通讯作者)，Tongji Univ, Shanghai Peoples Hosp 10, Sch Med, Inst Energy Metab & Hlth, Shanghai 200072, Peoples R China.;Chai, ZT (通讯作者)，Fudan Univ, Liver Canc Inst, Key Lab Carcinogenesis & Canc Invas, Minist Educ,Dept Liver Surg & Transplantat, Shanghai 200032, Peoples R China.;Chai, ZT (通讯作者)，Fudan Univ, Zhongshan Hosp, Shanghai 200032, Peoples R China.;Chai, ZT (通讯作者)，Shanghai Geriatr Canc, Dept Hepat Surg, Shanghai 201104, Peoples R China.

MOLECULES, 2023; 28 (6):

Abstract

Fibroblast growth factor receptors (FGFRs) play critical roles in the regulation of cell growth, differentiation, and proliferation. Specifically, FGF......

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