One amino acid in mouse activated factor VII defines its endothelial protein C receptor (EPCR) binding and modulates its EPCR-dependent hemostatic activity in vivo

Pavani, G; Zintner, SM; Ivanciu, L; Small, JC; Stafford, KA; Szeto, JH; Margaritis, P

Margaritis, P (reprint author), Childrens Hosp Philadelphia, 5024 Colket Translat Res Bldg,3501 Civ Ctr Blvd, Philadelphia, PA 19104 USA.

JOURNAL OF THROMBOSIS AND HAEMOSTASIS, 2017; 15 (3): 507

Abstract

Background Human activated factor VII (hFVIIa), which is used in hemophilia treatment, binds to the endothelial protein C (PC) receptor (EPCR) with un......

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