Brain accumulation of tivozanib is restricted by ABCB1 (P-glycoprotein) and ABCG2 (breast cancer resistance protein) in mice

Wang, J; Bruin, MAC; Gan, CP; Lebre, MC; Rosing, H; Beijnen, JH; Schinkel, AH

Schinkel, AH (corresponding author), Netherlands Canc Inst, Div Pharmacol, Plesmanlaan 121, Amsterdam 1066 CX, Netherlands.

INTERNATIONAL JOURNAL OF PHARMACEUTICS, 2020; 581 ():

Abstract

Tivozanib is a potent and selective inhibitor of VEGFR1-3, recently approved by the EMA for first-line treatment of renal cell carcinoma. We used wild......

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