c-MPL provides tumor-targeted T-cell receptor-transgenic T cells with costimulation and cytokine signals

Nishimura, CD; Brenner, DA; Mukherjee, M; Hirsch, RA; Ott, L; Wu, MF; Liu, H; Dakhova, O; Orange, JS; Brenner, MK; Lin, CY; Arber, C

Arber, C (reprint author), Univ Lausanne, Dept Oncol, CHU Vaudois, Ludwig Inst Canc Res,Lausanne Branch, Chemin Boveresses 155, CH-1066 Epalinges, Switzerland.

BLOOD, 2017; 130 (25): 2739

Abstract

Adoptively transferred T-cell receptor (TCR)-engineered T cells depend on host-derived costimulation and cytokine signals for their full and sustained......

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