Colorectal Cancer-Associated Smad4 R361 Hotspot Mutations Boost Wnt/beta-Catenin Signaling through Enhanced Smad4-LEF1 Binding

Lanauze, CB; Sehgal, P; Hayer, K; Torres-Diz, M; Pippin, JA; Grant, SFA; Thomas-Tikhonenko, A

Thomas-Tikhonenko, A (corresponding author), Childrens Hosp Philadelphia, Dept Pathol & Lab Med, 4056 Colket Translat Res Bldg, Philadelphia, PA 19104 USA.; Thomas-Tikhonenko, A (corresponding author), Univ Penn, 4056 Colket Translat Res Bldg, Philadelphia, PA 19104 USA.

MOLECULAR CANCER RESEARCH, 2021; 19 (5): 823

Abstract

About 10% to 30% of patients with colorectal cancer harbor either loss of or missense mutations in SMAD4, a critical component of the TGF beta signali......

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