Loss of PRSS56 function leads to ocular angle defects and increased susceptibility to high intraocular pressure

Labelle-Dumais, C; Pyatla, G; Paylakhi, S; Tolman, NG; Hameed, S; Seymens, Y; Dang, E; Mandal, AK; Senthil, S; Khanna, RC; Kabra, M; Kaur, I; John, SWM; Chakrabarti, S; Nair, KS

Nair, KS (corresponding author), Univ Calif San Francisco, Dept Ophthalmol, San Francisco, CA 94143 USA.; Chakrabarti, S (corresponding author), LV Prasad Eye Inst, Brien Holden Eye Res Ctr, Hyderabad 500034, India.; Nair, KS (corresponding author), Univ Calif San Francisco, Dept Anat, San Francisco, CA 94143 USA.

DISEASE MODELS & MECHANISMS, 2020; 13 (5):

Abstract

Glaucoma is a leading cause of blindness, affecting up to 70 million people worldwide. High intraocular pressure (IOP) is a major risk factor for glau......

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