Desmoplastic stroma restricts T cell extravasation and mediates immune exclusion and immunosuppression in solid tumors

Xiao, ZB; Todd, L; Huang, L; Noguera-Ortega, E; Lu, Z; Huang, LL; Kopp, M; Li, Y; Pattada, N; Zhong, WQ; Guo, W; Scholler, J; Liousia, M; Assenmacher, CA; June, CH; Albelda, SM; Puré, E

Puré, E (通讯作者)，Univ Penn, Dept Biomed Sci, Philadelphia, PA 19104 USA.

NATURE COMMUNICATIONS, 2023; 14 (1):

Abstract

Tumor stroma is a key component of the immunosuppressive tumor microenvironment in pancreatic ductal adenocarcinoma (PDAC). Here, in preclinical PDAC ......

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