Selective PARP1 inhibitors, PARP1-based dual-target inhibitors, PROTAC PARP1 degraders, and prodrugs of PARP1 inhibitors for cancer therapy

Peng, XP; Pan, WY; Jiang, F; Chen, WM; Qi, ZT; Peng, WJ; Chen, JJ

Peng, WJ (通讯作者)，Gannan Med Univ, Sch Pharm, Key Lab Prevent & Treatment Cardiovasc & Cerebrova, Minist Educ,Jiangxi Prov Key Lab Biomat & Biofabri, Ganzhou 314000, Peoples R China.;Chen, JJ (通讯作者)，Southern Med Univ, Sch Pharmaceut Sci, Guangdong Prov Key Lab New Drug Screening, NMPA Key Lab Res & Evaluat Drug Metab, Guangzhou 510515, Peoples R China.

PHARMACOLOGICAL RESEARCH, 2022; 186 ():

Abstract

Poly ADP-ribose polymerase (PARP) plays a critical role in many cellular processes such as DNA damage repair, gene transcription and cell apoptosis. T......

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