IL-6 Improves Energy and Glucose Homeostasis in Obesity via Enhanced Central IL-6 trans-Signaling

Timper, K; Denson, JL; Steculorum, SM; Heilinger, C; Engstrom-Ruud, L; Wunderlich, CM; Rose-John, S; Wunderlich, FT; Bruning, JC

Wunderlich, FT; Bruning, JC (reprint author), Max Planck Inst Metab Res, Dept Neuronal Control Metab, Gleueler Str 50, D-50931 Cologne, Germany.; Wunderlich, FT; Bruning, JC (reprint author), Univ Hosp Cologne, Ctr Endocrinol Diabet & Prevent Med CEDP, Ke

CELL REPORTS, 2017; 19 (2): 267

Abstract

Interleukin (IL)-6 engages similar signaling mechanisms to leptin. Here, we find that central application of IL-6 in mice suppresses feeding and impro......

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