Synthesis of benzopyran derivatives as PPAR alpha and/or PPAR gamma activators

Bermejo, A; Barrachina, I; El Aouad, N; Franck, X; Chahboune, N; Andreu, I; Figadere, B; Vila, L; Hennuyer, N; Staels, B; Dacquet, C; Caignard, DH; Sanz, MJ; Cortes, D; Cabedo, N

Sanz, MJ; Cortes, D; Cabedo, N (reprint author), Univ Valencia, Dept Farmacol, Valencia, Spain.

BIOORGANIC & MEDICINAL CHEMISTRY, 2019; 27 (24):

Abstract

We describe the synthesis of 26 compounds, small polycerasoidol analogs, that are Lipinski's rule-of-five compliant. In order to confirm key structura......

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