FVIII proteins with a modified immunodominant T-cell epitope exhibit reduced immunogenicity and normal FVIII activity

Ettinger, RA; Liberman, JA; Gunasekera, D; Puranik, K; James, EA; Thompson, AR; Pratt, KP

Pratt, KP (reprint author), Uniformed Serv Univ Hlth Sci, 4301 Jones Bridge Rd, Bethesda, MD 20814 USA.

BLOOD ADVANCES, 2018; 2 (4): 309

Abstract

Factor VIII (FVIII)-neutralizing antibodies (inhibitors) are a serious complication in hemophilia A (HA). The peptide FVIII2194-2213 contains an immun......

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