Hypoxia Inducible Factor-1 alpha (HIF-1 alpha) Mediates NLRP3 Inflammasome-Dependent-Pyroptotic and Apoptotic Cell Death Following Ischemic Stroke

Jiang, Q; Geng, XK; Warren, J; Cosky, EEP; Kaura, S; Stone, C; Li, FW; Ding, YC

Geng, XK (corresponding author), Capital Med Univ, Beijing Luhe Hosp, Dept Neurol, 82 Xinhua South Rd, Beijing 101149, Peoples R China.; Ding, YC (corresponding author), Wayne State Univ, Sch Med, Dept Neurosurg, 550 E Canfield, Detroit, MI 48201 USA.

NEUROSCIENCE, 2020; 448 (): 126

Abstract

Stroke is a major cause of death and long-term disability. Recent evidence suggests that hypoxia-inducible factor 1 alpha (HIF-1 alpha), a transcripti......

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