Assessments of CYP-inhibition-based drug-drug interaction between vonoprazan and poziotinib in vitro and in vivo

Zhou, S; Zhao, FL; Wang, SH; Wang, YR; Hong, Y; Zhou, Q; Geng, PW; Luo, QF; Cai, JP; Dai, DP

Cai, JP; Dai, DP (通讯作者)，Beijing Hosp, Beijing Inst Geriatr, Inst Geriatr Med, Key Lab Geriatr,Natl Ctr Gerontol Natl Hlth Commis, Beijing 100730, Peoples R China.;Luo, QF (通讯作者)，Beijing Hosp, Natl Ctr Gerontol, Dept Gastroenterol, Beijing 100730, Peoples R China.

PHARMACEUTICAL BIOLOGY, 2023; 61 (1): 356

Abstract

Context Poziotinib and vonoprazan are two drugs mainly metabolized by CYP3A4. However, the drug-drug interaction between them is unknown. Objective To......

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