Regulatable interleukin-12 gene therapy in patients with recurrent high-grade glioma: Results of a phase 1 trial

Chiocca, EA; Yu, JS; Lukas, RV; Solomon, IH; Ligon, KL; Nakashima, H; Triggs, DA; Reardon, DA; Wen, P; Stopa, BM; Naik, A; Rudnick, J; Hu, JL; Kumthekar, P; Yamini, B; Buck, JY; Demars, N; Barrett, JA; Gelb, AB; Zhou, J; Lebel, F; Cooper, LJN

Chiocca, EA (reprint author), Harvard Med Sch, Brigham & Womens Hosp, Dept Neurosurg, Boston, MA 02115 USA.; Chiocca, EA (reprint author), Dana Farber Canc Inst, Ctr Neurooncol, Boston, MA 02115 USA.

SCIENCE TRANSLATIONAL MEDICINE, 2019; 11 (505):

Abstract

Human interleukin-12 (hIL-12) is a cytokine with anticancer activity, but its systemic application is limited by toxic inflammatory responses. We asse......

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