The DNMT3A R882H mutation does not cause dominant negative effects in purified mixed DNMT3A/R882H complexes

Emperle, M; Dukatz, M; Kunert, S; Holzer, K; Rajavelu, A; Jurkowska, RZ; Jeltsch, A

Jeltsch, A (reprint author), Stuttgart Univ, Inst Biochem & Tech Biochem, Dept Biochem, Allmandring 31, D-70569 Stuttgart, Germany.

SCIENTIFIC REPORTS, 2018; 8 ():

Abstract

The DNA methyltransferase DNMT3A R882H mutation is observed in 25% of all AML patients. DNMT3A is active as tetramer and the R882H mutation is located......

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