Digenic DUOX1 and DUOX2 Mutations in Cases With Congenital Hypothyroidism

Aycan, Z; Cangul, H; Muzza, M; Bas, VN; Fugazzola, L; Chatterjee, VK; Persani, L; Schoenmakers, N

Schoenmakers, N (reprint author), Univ Cambridge, Addenbrookes Hosp, Metab Res Labs, Wellcome Trust Med Res Council,Inst Metab Sci, Level 4,Box 289,Hills Rd, Cambridge CB2 0QQ, England.

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 2017; 102 (9): 3085

Abstract

Context: The DUOX2 enzyme generates hydrogen peroxide (H2O2), a crucial electron acceptor for the thyroid peroxidase-catalyzed iodination and coupling......

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