Conjugation of DM1 to anti-CD30 antibody has potential antitumor activity in CD30-positive hematological malignancies with lower systemic toxicity

Shen, YJ; Yang, T; Cao, XM; Zhang, YF; Zhao, L; Li, H; Zhao, T; Xu, J; Zhang, HB; Guo, QS; Cai, JL; Gao, B; Yu, HL; Yin, SC; Song, RW; Wu, JS; Guan, LY; Wu, GH; Jin, L; Su, Y; Liu, YJ

Su, Y (reprint author), Shanghai Fudan Zhangjiang Biopharmaceut Co Ltd, R&D Dept Genet Engn, Shanghai, Peoples R China.

MABS, 2019; 11 (6): 1149

Abstract

An anti-CD30 antibody-drug conjugate incorporating the antimitotic agent DM1 and a stable SMCC linker, anti-CD30-MCC-DM1, was generated as a new antit......

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