HPV E2, E4, E5 drive alternative carcinogenic pathways in HPV positive cancers

Ren, SL; Gaykalova, DA; Guo, T; Favorov, AV; Fertig, EJ; Tamayo, P; Callejas-Valera, JL; Allevato, M; Gilardi, M; Santos, J; Fukusumi, T; Sakai, A; Ando, M; Sadat, S; Liu, C; Xu, GR; Fisch, KM; Wang, ZY; Molinolo, AA; Gutkind, JS; Ideker, T; Koch, WM; Califano, JA

Califano, JA (corresponding author), Univ Calif San Diego, Moores Canc Ctr, La Jolla, CA 92093 USA.; Califano, JA (corresponding author), Univ Calif San Diego, Dept Surg, Div Otolaryngol Head & Neck Surg, La Jolla, CA 92093 USA.

ONCOGENE, 2020; 39 (40): 6327

Abstract

The dominant paradigm for HPV carcinogenesis includes integration into the host genome followed by expression of E6 and E7 (E6/E7). We explored an alt......

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