Design, Synthesis, and Characterization of I-BET567, a Pan-Bromodomain and Extra Terminal (BET) Bromodomain Oral Candidate

Humphreys, PG; Atkinson, SJ; Bamborough, P; Bit, RA; Chung, CW; Craggs, PD; Cutler, L; Davis, R; Ferrie, A; Gong, GL; Gordon, LJ; Gray, M; Harrison, LA; Hayhow, TG; Haynes, A; Henley, N; Hirst, DJ; Holyer, ID; Lindon, MJ; Lovatt, C; Lugo, D; McCleary, S; Molnar, J; Osmani, Q; Patten, C; Preston, A; Rioja, I; Seal, JT; Smithers, N; Sun, FL; Tang, DL; Taylor, S; Theodoulou, NH; Thomas, C; Watson, RJ; Wellaway, CR; Zhu, LR; Tomkinson, NCO; Prinjha, RK

Humphreys, PG (通讯作者)，GlaxoSmithKline R&D, Stevenage SG1 2NY, Herts, England.

JOURNAL OF MEDICINAL CHEMISTRY, 2022; 65 (3): 2262

Abstract

Through regulation of the epigenome, the bromodomain and extra terminal (BET) family of proteins represent important therapeutic targets for the treat......

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