Discovery of Zanubrutinib (BGB-3111), a Novel, Potent, and Selective Covalent Inhibitor of Bruton's Tyrosine Kinase

Guo, YH; Liu, Y; Hu, N; Yu, DS; Zhou, CY; Shi, GY; Zhang, B; Wei, M; Liu, JH; Luo, LS; Tang, ZY; Song, HP; Guo, Y; Liu, XS; Su, D; Zhang, S; Song, XM; Zhou, X; Hong, Y; Chen, SS; Cheng, ZZ; Young, S; Wei, Q; Wang, HS; Wang, QW; Lv, L; Wang, F; Xu, HP

Wang, ZW (reprint author), BeiGene Beijing Co Ltd, Dept Med Chem, 30 Sci Pk Rd,Zhong Guan Cun Life Sci Pk, Beijing 102206, Peoples R China.

JOURNAL OF MEDICINAL CHEMISTRY, 2019; 62 (17): 7923

Abstract

Aberrant activation of Bruton's tyrosine kinase (BTK) plays an important role in pathogenesis of B-cell lymphomas, suggesting that inhibition of BTK i......

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