Bruton tyrosine kinase degradation as a therapeutic strategy for cancer

Dobrovolsky, D; Wang, ES; Morrow, S; Leahy, C; Faust, T; Nowak, RP; Donovan, KA; Yang, G; Li, ZN; Fischer, ES; Treon, SP; Weinstock, DM; Gray, NS

Weinstock, DM (reprint author), Dana Farber Canc Inst, Dept Med Oncol, Dana 510B,450 Brookline Ave, Boston, MA 02115 USA.; Gray, NS (reprint author), Dana Farber Canc Inst, Dept Canc Biol, Longwood Ctr, Room 2209,360 Longwood Ave, Boston, MA 02215 USA.

BLOOD, 2019; 133 (9): 952

Abstract

The covalent Bruton tyrosine kinase (BTK) inhibitor ibrutinib is highly efficacious against multiple B-cell malignancies. However, it is not selective......

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