Evidence for Decreased Nucleolar PARP-1 as an Early Marker of Cognitive Impairment

Regier, M; Liang, JC; Choi, A; Verma, K; Libien, J; Hernandez, AI

Hernandez, AI (reprint author), Suny Downstate Med Ctr, Dept Pathol, Brooklyn, NY 11203 USA.; Hernandez, AI (reprint author), Suny Downstate Med Ctr, Robert F Furchgott Ctr Neural & Behav Sci, Brooklyn, NY 11203 USA.

NEURAL PLASTICITY, 2019; 2019 ():

Abstract

Poly(ADP-ribose) polymerase-1 (PARP-1) is a nuclear protein that regulates gene expression through poly(ADP)-ribosylation, resulting in the loosening ......

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