JAM3 maintains leukemia-initiating cell self-renewal through LRP5/AKT/beta-catenin/CCND1 signaling

Zhang, YP; Xia, FZ; Liu, XY; Yu, Z; Xie, L; Liu, LG; Chen, CQ; Jiang, HS; Hao, XX; He, XX; Zhang, FF; Gu, H; Zhu, J; Bai, HT; Zhang, CC; Chen, GQ; Zheng, JK

Zheng, JK (reprint author), Shanghai Jiao Tong Univ, Sch Med, Dept Pathophysiol, 280 South Chongqing Rd, Shanghai 200025, Peoples R China.

JOURNAL OF CLINICAL INVESTIGATION, 2018; 128 (5): 1737

Abstract

Leukemia-initiating cells (LICs) are responsible for the initiation, development, and relapse of leukemia. The identification of novel therapeutic LIC......

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