CARD9(+) microglia promote antifungal immunity via IL-1 beta- and CXCL1-mediated neutrophil recruitment

Drummond, RA; Swamydas, M; Oikonomou, V; Zhai, B; Dambuza, IM; Schaefer, BC; Bohrer, AC; Mayer-Barber, KD; Lira, SA; Iwakura, Y; Filler, SG; Brown, GD; Hube, B; Naglik, JR; Hohl, TM; Lionakis, MS

Drummond, RA; Lionakis, MS (reprint author), NIAID, Fungal Pathogenesis Sect, Lab Clin Immunol & Microbiol, NIH, 9000 Rockville Pike, Bethesda, MD 20892 USA.; Drummond, RA (reprint author), Univ Birmingham, Inst Immunol & Immunotherapy, Inst Microbiol & I

NATURE IMMUNOLOGY, 2019; 20 (5): 559

Abstract

The C-type lectin receptor-Syk (spleen tyrosine kinase) adaptor CARD9 facilitates protective antifungal immunity within the central nervous system (CN......

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