Distinct CDK6 complexes determine tumor cell response to CDK4/6 inhibitors and degraders

Wu, XW; Yang, XB; Xiong, Y; Li, RT; Ito, T; Ahmed, TA; Karoulia, Z; Adamopoulos, C; Wang, H; Wang, L; Xie, L; Liu, J; Ueberheide, B; Aaronson, SA; Chen, X; Buchanan, SG; Sellers, WR; Jin, J; Poulikakos, PI

Poulikakos, PI (corresponding author), Icahn Sch Med Mt Sinai, Dept Oncol Sci, Tisch Canc Inst, New York, NY 10029 USA.

NATURE CANCER, ; ():

Abstract

Cyclin-dependent kinases (CDKs) 4 and 6 inhibitors (CDK4/6is) are effective in metastatic breast cancer, but they have been only modestly effective in......

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