Pharmacokinetics of tenofovir monoester and association with intracellular tenofovir diphosphate following single-dose tenofovir disoproxil fumarate

Brooks, KM; Ibrahim, ME; Castillo-Mancilla, JR; MaWhinney, S; Alexander, K; Tilden, S; Kerr, BJ; Ellison, L; McHugh, C; Bushman, LR; Kiser, JJ; Hosek, S; Huhn, GD; Anderson, PL

Anderson, PL (reprint author), Univ Colorado, Skaggs Sch Pharm & Pharmaceut Sci, 12850 E Montview Blvd,V20-C238, Aurora, CO 80045 USA.

JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY, 2019; 74 (8): 2352

Abstract

Background: Tenofovir monoester is a relatively lipophilic intermediate formed during the hydrolysis of tenofovir disoproxil to tenofovir. Its clinica......

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